团队带头人简介：贾立军，男，教授，博士生导师，现任南京中医药大学中西医结合学院院长。曾任上海中医药大学中西医结合学科首席教授，上海市中医药研究院中医肿瘤研究所所长；国家杰出青年科学基金获得者，中青年科技创新领军人才；上海市优秀学术带头人，上海市领军人才。从事肿瘤发生机理与中西医防治策略研究，迄今在Nat Commun、J Natl Cancer Inst、Cancer Res、Clin Cancer Res、 Autophagy、Cell Death Differ、Acta Pharm. Sin. B、Redox Biol和Phytomedicine等期刊发表SCI论文80余篇。获邀担任Signal Transduct Target Ther等学术期刊编委，参编英文专著4部。主持国家自然科学基金委杰出青年科学基金、国家重大科学研究计划（课题负责人）和国家自然科学基金重点国际（地区）合作研究项目等科研项目15项。获邀担任国家自然科学基金委员会医学科学领域学科评审组专家、中国抗癌协会整合肿瘤学专委会副主任委员、中国抗癌协会肿瘤微环境专委会常务委员、中国中西医结合学会肿瘤专委会常务委员、上海医师协会整合医学分会副会长等。

电子邮箱：jialijun2002@aliyun.com

      一、团队研究方向

肿瘤发生机理与中西医防治策略

      二、团队研究内容

（1）新型促癌信号通路鉴定与药物筛选；（2）扶正治癌理论内涵与临床转化研究；（3）情志失调致病机理与中医干预策略；（4）节食禁食调控身心健康的效应机制。

三、发表论文

1. Feng Zhu, Liangshan Li, Yuanyuan Chen, Yongfu Pan, Wenjuan Zhang, Lihui Li, Lili Cai, Xiaoxue Zhao, Hu Zhao, Shiwen Wang*, Lijun Jia*. CRL3Keap1 E3 ubiquitin ligase facilitates ubiquitin-mediated degradation of oncogenic SRX to suppress colorectal cancer progression. Nature Communications. Accepted.

2. Yuxuan Zhang, Biying Xiao, Shuying Yuan, Lele Ding, Yongfu Pan, Yanyu Jiang, Shenghao Sun, Xisong Ke, Lili Cai*, Lijun Jia*. Tryptanthrin targets GSTP1 to induce senescence and increases the susceptibility to apoptosis by senolytics in liver cancer cells. Redox Biology. 2024, 20:76:103323.

3. Yupei Liang, Ping Chen, Shiwen Wang, Lili Cai, Feng Zhu, Yanyu Jiang, Lihui Li, Lihua Zhu, Yongqing Heng, Wenjuan Zhang, Yongfu Pan, Wenyi Wei, Lijun Jia*. SCFFBXW5-mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells, Autophagy. 2024, 20(9):1984-1999.

4. Shuaishuai Ni#, Qian Liu#, Xin Chen#, Lele Ding#, Lili Cai, Fei Mao, Donglei Shi, Robert M Hoffman, Jian Li, Lijun Jia*. Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells. Signal transduction and targeted therapy. 2022, 7(1): 313.

5. Zhang L, Li L, Chen X, Yuan S, Xu T, Zhao W, Li M, Wang F, Hoffman RM, Jia L. Evodiamine inhibits ESCC by inducing M-phase cell-cycle arrest via CUL4A/p53/p21 axis and activating noxa-dependent intrinsic and DR4-dependent extrinsic apoptosis.Phytomedicine. 2023;108:154493.

6. Zhang J, Li C, Zhang L, Heng Y, Wang S, Pan Y, Cai L, Zhang Y, Xu T, Chen X, Hoffman RM, Jia L.Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27.Phytomedicine. 2022;98:153933.

7. Wenjuan Zhang#, Lihui Li#, Lili Cai#, Yupei Liang, Junfeng Xu, Yue Liu, Lisha Zhou, Chen Ding, Yanmei Zhang, Hu Zhao, Jun Qin, Zhimin Shao, Wenyi Wei, Lijun Jia*. Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as receptor protein of CRL2PRAME complex. Cell Death Differ. 2021, 28(6):1926-1940.

8. Cai L, Li L, Chen X, Jia L.Regulation of SKP2 protein stability by heat shock protein 90 chaperone machinery.Signal Transduct Target Ther. 2021 Jul 30;6(1):276.

9. Lisha Zhou#, Yanyu Jiang#, Xiaojun Liu#, Lihui Li, Xuguang Yang, Changsheng Dong, Xiaoli Liu, Yuli Lin, Yan Li, Jinha Yu, Rui He, Shenglin Huang, Guangwei Liu, Yanmei Zhang, Lak Shin Jeong, Robert M. Hoffman, Lijun Jia*. Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer. Oncogene. 2019, 38(29):5792-5804.

10. Ni S, Chen X, Yu Q, Xu Y, Hu Z, Zhang J, Zhang W, Li B, Yang X, Mao F, Huang J, Sun Y, Li J, Jia L.Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth.Eur J Med Chem. 2020 Jan 1;185:111848. doi: 10.1016/j.ejmech.2019.111848. Epub 2019 Nov 4.

11. Jia X, Li C, Li L, Liu X, Zhou L, Zhang W, Ni S, Lu Y, Chen L, Jeong LS, Yu J, Zhang Y, Zhang J, He S, Hu X, Sun H, Yu K, Liu G, Zhao H, Zhang Y, Jia L, Shao ZM.Neddylation Inactivation Facilitates FOXO3a Nuclear Export to Suppress Estrogen Receptor Transcription and Improve Fulvestrant Sensitivity.Clin Cancer Res. 2019 Jun 15;25(12):3658-3672. 

12. Li L, Kang J, Zhang W, Cai L, Wang S, Liang Y, Jiang Y, Liu X, Zhang Y, Ruan H, Chen G, Wang M, Jia L.Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer.EBioMedicine. 2019 Jul;45:81-91.

13. Chen P, Hu T, Liang Y, Li P, Chen X, Zhang J, Ma Y, Hao Q, Wang J, Zhang P, Zhang Y, Zhao H, Yang S, Yu J, Jeong LS, Qi H, Yang M, Hoffman RM, Dong Z, Jia L.Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4-CHOP-DR5 Axis in Human Esophageal Cancer Cells.Clin Cancer Res. 2016 Aug 15;22(16):4145-57

14. Li L, Wang M, Yu G, Chen P, Li H, Wei D, Zhu J, Xie L, Jia H, Shi J, Li C, Yao W, Wang Y, Gao Q, Jeong LS, Lee HW, Yu J, Hu F, Mei J, Wang P, Chu Y, Qi H, Yang M, Dong Z, Sun Y, Hoffman RM, Jia L.Overactivated neddylation pathway as a therapeutic target in lung cancer.J Natl Cancer Inst. 2014 May 22;106(6):dju083

15. Yang D, Li L, Liu H, Wu L, Luo Z, Li H, Zheng S, Gao H, Chu Y, Sun Y, Liu J, Jia L.Induction of autophagy and senescence by knockdown of ROC1 E3 ubiquitin ligase to suppress the growth of liver cancer cells.Cell Death Differ. 2013 Feb;20(2):235-47.

16. Luo Z, Yu G, Lee HW, Li L, Wang L, Yang D, Pan Y, Ding C, Qian J, Wu L, Chu Y, Yi J, Wang X, Sun Y, Jeong LS, Liu J, Jia L.The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth.Cancer Res. 2012 Jul 1;72(13):3360-71

四、在研项目

团队带头人简介：吕志刚，博士，教授，博士生导师，南京中医药大学中西医结合学院副院长，江苏省中医院肿瘤科主任中医师。入选国家青年岐黄学者，江苏特聘教授，江苏省中医药领军人才，江苏省第十六批六大人才（B类）。曾长期在美国纪念斯隆凯特癌症中心担任助理研究员，后被南京中医药大学以海外高层次人才引进。回国后长期专注于中医药对肿瘤和疼痛的多维干预。近5年主持国家自然科学基金面上项目（3项）和科技部重点研发计划课题。分别在JCI、PNAS、Journal of Neuroscience等期刊发表一系列阿片药理研究成果。目前为中国针灸学会针刺麻醉分会副主任委员、中华中医药学会慢病管理分会副秘书长和常务委员、江苏省中医药学会慢病管理分会副主任委员等学术兼职。

电子邮箱：luzg@njucm.edu.cn

一、团队研究方向

团队专注于中医药对阿片类药物减毒增效研究及中医药多维干预疼痛的机制研究。

二、研究内容

（1）创制新型戒毒中医药制剂，开展中药复方511抗药物成瘾临床药效和分子机制研究。（2）针药结合阿片药物减毒增效研究。

三、发表论文

1. Xu J#, Lu ZG#, Ankita N#, Le Rouzic V, Xu MM, Brown T, Hoefer W, Rossi GC, Richard R, Arlene MP, Rajadhyaksha AM, Catergni L, Pasternak GW, Pan Y-X*. Alternatively spliced Ctermini of mu opioid receptors impact morphine actions. J Clin Invest. 2017 Apr 3;127(4):1561-1573. IF:19.456

2. Lu ZG, Xu J, GC Rossi, S Majumdar, GW Pasternak, Y-X Pan*. Mediation of opioid analgesia by truncated six transmembrane G protein-coupled receptors. J Clin Invest. 2015 Jul 1;125(7):2626-30. IF:19.456

3. Ji JJ#, Sun QM#, W Q, Liu AL, Zhang H, Qin FF, Wang QS, Lu SF, Pang GM*, Lu ZG*. Probiotics suppresses RSV inflammation through modulating lung microbiotass inducing antiviral responses of alveolar macrophage. Acta Pharmacol Sin. 2021 Oct;42(10):1630-1641. IF: 7.169

4. Li ZH#, Sun QM#, Zhang H, Ji JJ, Qin FF, Wang QS, Nie DY, Liu AL, Jiang YW, Lu SF, Lu ZG*. Compound 511 attenuates the mice morphine immunosuppression via regulatingTh1/Th2 and Th17/Treg balance mediated by the PI3K/AKT/mTOR pathway. Phytomedicine. January 2023, 154475. IF: 7.9

5. Wang QS#, Qin FF#, Liu QY, Wang H, Lu S, Li ZH, Wang ZJ, Lin WX,Jiang YW, Lu SF, Wang Q, Lu ZG*. Compound 511 exerts anti-morphine replapse effect through G9aH3K9me2-ΔFosB pathway in the Nucleus Accumbens. Phytomedicine. January 2023, 154467. IF:7.9

6. Jiang YW, Lu SF, Wang Q, Lu ZG*. Compound 511 exerts anti-morphine replapse effect through G9aH3K9me2-ΔFosB pathway in the Nucleus Accumbens. Phytomedicine. January 2023, 154467. IF:7.9

7. Sun Q, Li Z, Wang Z, Wang Q, Qin F, Pan H, Lin W, Mu X, Wang Y, Jiang Y, Ji J, Lu ZG*. Immunosuppression by opioids: Mechanisms of action on innate and adaptive immunity. Biochem Pharmacol. 2023 Mar;209:115417. IF: 6.1

8. Zhang H, Qin FF, Liu AL, Sun QM, Wang QS, Lu SF, Lu ZG*. Effects of electroacupuncture on PI3K/AKT/mTOR pathway in premature ovarian failure mice. Life Sci. 2019 Jan 15;217:169-175. IF: 6.78

9. Pan HT, Huang J, Zhou Z, Mu X, Wang Y, Wang Q, Lu ZG*. The role of microglia in drug addiction. Asian J Psychiatr. 2023 Dec;90:103827. 2023 Nov 2. IF: 9.2

10. Qin FF#, Wang QS#, Liu AL, Liu QY, Wang H, Lu S, Li ZH, Lin WX, Wang ZJ, Jiang YW, Lu SF, Lu ZG*.A truncated six transmembrane μ-opioid receptors is essential for Exoticin analgesia. Phytomedicine. IF: 6.5

四、在研项目

团队带头人简介：陶伟伟，博士，教授，博士生导师，南京中医药大学中西医结合学院副院长，兼任中国中西医结合学会第九届教育工作委员会委员、中华中医药学会神志病分会委员会委员、江苏省中医养生学会脾胃养生分会委员会副主任委员。近年来，先后主持科研项目11项，其中包括3项国家自然基金、1项省重点研发计划等。近3年来，以第一作者或通讯作者发表学术论文20余篇，包括Sig Transduct Target Ther、Acta Pharm Sin B、Biomaterials等。申请并获得授权发明专利10余项，并转让1项。入选Elsevier中医药领域全球前2%顶尖科学家榜单。

电子邮箱：taoww@njucm.edu.cn

一、团队研究方向

中西医结合防治情志病研究

二、研究内容

团队专注于情绪障碍、认知功能障碍及中医药作用机制的前沿研究，配备了高分辨率成像、电生理记录、分子生物学与遗传学及行为学测试等尖端技术平台。团队成员掌握了最前沿的科研技术，参与发表了高水平期刊论文，共同致力于中西医结合防治情志病研究。

三、发表论文

1. Xiaoyu Wu, Zijun Bai, Hui Wang, Hanqing Wang, Dahai Hou, Yunzhu Xu, Guanqun Wo, Haibo Cheng, Dongdong Sun, Weiwei Tao*. CRISPR-Cas9 gene editing strengthened cuproptosis/chemodynamic/ferroptosis synergistic cancer therapy. 2024, 14: 4059-4072

2. Yue Hu, Min Zhao, Hui Wang, Yang Guo, Xiaolan Cheng, Tong Zhao, Hanqing Wang, Yafeng Zhang, Yong Ma, Weiwei Tao*. Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression. Journal of Nanobiotechnology, 2023, 21(1): 261.

3. Weiwei Tao, Jie Ruan, Ruyan Wu, MinZhao, Tong Zhao, Mingming Qi, Sonata S.Y.Yau, Guangda Yao, Hongru Zhang, YueHu, Gang Chen*. A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling[J]. Journal of Advanced Research, 2023, 43: 219–231

4. Weiwei Tao, Xiaolan Cheng, Dongdong Sun, Yang Guo, Neng Wang, Jie Ruan,Yue Hu, Min Zhao, Tong Zhao, Hui Feng, Lu Fan, Cai Lu, Yong Ma, Jinao Duan,Ming Zhao, Synthesis of Multibranched Au Nanocomposites with Distinct Plasmon Resonance in NIR-II Window and Controlled CRISPR-Cas9 Delivery for Synergistic Gene-photothermal Therapy, Biomaterials, 2022, 287: 121621

5. Weiwei Tao, Kunhan Su, Yuzhen Huang, Zihan Lu, Yan Wangc, Lu Yangc, Guoying Zhang, Wanli Liu. Zuojinwan ameliorates CUMS-induced depressive-like behavior through inducing ubiquitination of MyD88 via SPOP/MyD88/NF-κB pathway. Journal of Ethnopharmacology, 2023, 312: 116487

6. Weiwei Tao, Yuwen Hu, Zhaoyang Chen, Yuxin Da, Yue Hu, Mingming Qi*. Magnolol attenuates depressive-like behaviors by polarizing microglia towards the M2 phenotype through the regulation of Nrf2/HO-1/NLRP3 signaling pathway[J]. Phytomedicine, 2021,91: 153692.

四、在研项目

团队带头人简介：黄熙，生理学博士、中西医结合博士后(师从陈可冀院士)，教授、一级主任医师(教育部属院校标准)，国家杰出青年科学基金A类获得者，解放军总后科技新星和科技银星，湖南省首批20名医学领军人才，荣获2001年国家科技进步二等奖“方剂与证的药物动力学研究”和2011年湖南省科技进步一等奖“生物方剂分析药理研究策略的应用”。中西医结合/临床药理/生理/药理的硕/博士生导师、博士后合作导师。中国中西医结合学会基础理论专业委员会第七/八届主任委员。《江苏高校优势学科建设工程二/三期项目立项学科A等》学术带头人(中西医结合)、南京中医药大学高层次引进人才，任JMCC和Chinese Med J等10余种国内外杂志(通讯)编委或特约审稿专家。

电子邮箱：tcmhuangx59@163.com

一、团队研究方向

团队长期专注于中医药方剂及其药效物质成分锚定多病共享机制的研究，方剂与证的药物动力学的研究，生物方剂药理研究策略的研究，抑郁症与功能性消化不良共病的共享分子研究，以及快速精准揭示方剂功效成分的研究。

      二、研究内容

团队长期开展抑郁症、心血管、胃肠相关多病研究工作，能成功制备本项目研究中涉及的疾病模型。在长期的项目实施过程中，已经建立了本项目研究中涉及的行为学研究、药物分析、原代细胞共培养、离体-在体外推方法和离体靶器官张力研究。本团队为教育部重点实验室，有较强的科研学术梯队，设备齐全，实验室管理完善。从技术手段上，团队所使用实验方法比较成熟。

      三、发表论文

1. Huang, Y., Xu, M., Li, J., Chen, K., Xia, L., Wang, W., Ren, P., & Huang, X.# (2021). Ex vivo to in vivo extrapolation of syringic acid and ferulic acid as grape juice proxies for endothelium-dependent vasodilation: Redefining vasoprotective resveratrol of the French paradox. Food chemistry, 363, 130323. IF:8.5

2. Liu, X., Luo, M., Wang, Z., Yang, S. J., Su, M., Wang, Y., Wang, W., Sun, Z., Cai, Y., Wu, L., Zhou, R., Xu, M., Zhao, Q., Chen, L., Zuo, W., Huang, Y., Ren, P., & Huang, X#. (2024). Mind shift I: Fructus Aurantii - Rhizoma Chuanxiong synergistically anchors stress-induced depression-like behaviours and gastrointestinal dysmotility cluster by regulating psycho-immune-neuroendocrine network. Phytomedicine, 128, 155324. IF:6.7

3. Zhang, Y. J., Huang, W., Huang, X#., Wang, Y., Wang, Z., Wang, C., Zhong, B. W., Sheng, C. X., Wang, B., Zhang, S. F., Su, N. X., Liu, Z. Q., Zhou, H. H., & Ren, P. (2012). Fructus Aurantii induced antidepressant effect via its monoaminergic mechanism and prokinetic action in rat. Phytomedicine, 19(12), 1101–1107. IF:6.7

4. Huang, X#., Zhao, Q., Xia, L., & Shi, S. (2021). Letter to the Editor in response to the articles 'Lianhuaqingwen exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2)' and 'Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway.'. Pharmacological research, 163, 105289. IF:9.2

5. Zhao, Q., Liu, J., Chen, L., Gao, Z., Lin, M., Wang, Y., Xiao, Z., Chen, Y., & Huang, X#. (2024). Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR. Journal of ethnopharmacology, 323, 117703. IF 4.8

6. Wu L, Zhang T, Chen K, Lu C, Liu XF, Zhou JL, Huang YK, Yan H, Chen Y, Zhang CJ, Li JF, Shi SQ, Ren P, Huang X#. Rapid antidepressant-like effect of Fructus Aurantii depends on cAMP-response element binding protein/Brain-derived neurotrophic facto by mediating synaptic transmission. Phytother Res. 2021 Jan;35(1):404-414. doi: 10.1002/ptr.6812. Epub 2020 Oct 12. IF 6.1

四、获批项目

团队带头人简介：程向东，博士，教授，主任医师，博士生导师（外校兼职博导），皇家外科学院院士(FRCS)，美国外科学院院士(FACS)，享受国务院特殊津贴专家，第二十五届吴杨奖获得者。现任浙江省肿瘤医院党委书记，中国抗癌协会副理事长，科技部国家重点研发计划首席科学家，浙全省上消化道肿瘤防控与诊治重点实验室主任、肿瘤分子诊断与智能筛查浙江国际科技合作基地负责人、消化道肿瘤诊治创新技术浙江省工程研究中心主任、浙江省上消化道恶性肿瘤临床医学研究中心主任、浙江省上消化道肿瘤诊治技术研究中心主任。兼任中国抗癌协会胃癌整合防筛专委会主任委员，中国抗癌协会胃癌专业委员会副主任委员，中国医师协会肿瘤外科医师委员会副主任委员，浙江省医师协会肿瘤外科医师分会主任委员，浙江省抗癌协会胃肿瘤专业委员会主任委员，浙江省肿瘤微创外科联盟主席，浙江省医学会外科学分会副主任委员，浙江省抗癌协会副理事长，浙江省癌症基金会理事长。入选国家卫生健康突出贡献中青年专家、浙江省有突出贡献中青年专家、浙江省万人计划杰出人才、浙江省卫生领军人才。近五年获得国家级、省级和厅级重点项目和专项资助10多项，以通讯作者身份在Gut、Nature Communications、EClinicalMedicine、Microbiome、Oncogene等国际知名学术刊物上发表论文100余篇，出版专著4部，获得国家发明专利10项，软件著作权1项，作为第一完成人荣获浙江省科学技术进步奖一等奖、三等奖各1项。

电子邮箱：chengxd@zjcc.org.cn

一、团队研究方向及内容

1、构建胃癌多维早筛技术研发及防控体系：基于前期的“舌苔AI图像和舌苔微生物组学”序贯式筛查模型，继续开展全国多中心的临床研究验证明确该体系的有效性和敏感性，提高胃癌患者的早诊比例；基于多组学技术，优化和开发特异、便捷的癌症早筛系统，形成新的胃癌筛查指南。

2、全面解析晚期胃癌转移新机制，开展前瞻性临床研究，构建新型的胃癌分子分型：针对围手术期病人开展免疫治疗相关临床研究，开展双抗、ADC等药物用于晚期胃癌一线、二线治疗等临床研究，利用多组学技术建立胃癌综合治疗分子分型，对患者进行分层、分类治疗，提高胃癌综合治疗疗效，更新胃癌综合诊疗指南；采用前沿组学技术全面解析胃癌发生发展过程中肿瘤微环境变化，筛选一系列胃癌关键靶点，开展药物开发。

3、临床智能治疗技术研发与创新术式研究：整合临床、病理、影像、基因等全量多维数据，构建胃癌临床诊疗辅助决策系统；开展胃癌消化道重建术式的研发和推广，构建基于胃癌腹腔镜手术视频大模型，实现胃癌手术全流程质量控制管理。

二、2024年代表性论文（中科院1区TOP）

1. Cheng X, Dai E, Wu J, Flores NM, Chu Y, Wang R, Dang M, Xu Z, Han G, Liu Y, Chatterjee D, Hu C, Ying J, Du Y, Yang L, Guan X, Mo S, Cao X, Pei G, Jiang J, Lu X, Benitez AM, Waters RE, Pizzi MP, Shanbhag N, Fan Y, Peng F, Hanash SM, Calin G, Futreal A, Song S, Yee C, Mazur PK, Qin JJ, Ajani JA, Wang L. Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response. Gastroenterology. 2024 Dec;167(7):1345-1357. doi: 10.1053/j.gastro.2024.07.038. Epub 2024 Aug 2. PMID: 39097198.

2. Wei Q, Li P, Yang T, Zhu J, Sun L, Zhang Z, Wang L, Tian X, Chen J, Hu C, Xue J, Ma L, Shimura T, Fang J, Ying J, Guo P, Cheng X. The promise and challenges of combination therapies with antibody-drug conjugates in solid tumors. J Hematol Oncol. 2024 Jan 4;17(1):1. doi: 10.1186/s13045-023-01509-2. PMID: 38178200; PMCID: PMC10768262.

3. Wei Q, Yang T, Zhu J, Zhang Z, Yang L, Zhang Y, Hu C, Chen J, Wang J, Tian X, Shimura T, Fang J, Ying J, Fan M, Guo P, Cheng X. Spatiotemporal Quantification of HER2-targeting Antibody-Drug Conjugate Bystander Activity and Enhancement of Solid Tumor Penetration. Clin Cancer Res. 2024 Mar 1;30(5):984-997. doi: 10.1158/1078-0432.CCR-23-1725. PMID: 38113039.

4. Hu S, Hu C, Xu J, Yu P, Yuan L, Li Z, Liang H, Zhang Y, Chen J, Wei Q, Zhang S, Yang L, Su D, Du Y, Xu Z, Bai F, Cheng X. The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer. Nat Commun. 2024 Sep 30;15(1):8447. doi: 10.1038/s41467-024-52615-9. PMID: 39349474; PMCID: PMC11443007.

5. Yu P, Chen P, Wu M, Ding G, Bao H, Du Y, Xu Z, Yang L, Fang J, Huang X, Lai Q, Wei J, Yan J, Yang S, He P, Wu X, Shao Y, Su D, Cheng X. Multi-dimensional cell-free DNA-based liquid biopsy for sensitive early detection of gastric cancer. Genome Med. 2024 Jun 7;16(1):79. doi: 10.1186/s13073-024-01352-1. PMID: 38849905; PMCID: PMC11157707.

6. Chen J, Sun Y, Li J, Lyu M, Yuan L, Sun J, Chen S, Hu C, Wei Q, Xu Z, Guo T, Cheng X. In-depth metaproteomics analysis of tongue coating for gastric cancer: a multicenter diagnostic research study. Microbiome. 2024 Jan 8;12(1):6. doi: 10.1186/s40168-023-01730-8. PMID: 38191439; PMCID: PMC10773145.

7. Yu P, Hu C, Ding G, Shi X, Xu J, Cao Y, Chen X, Wu W, Xu Q, Fang J, Huang X, Yuan S, Chen H, Wang Z, Huang L, Pang F, Du Y, Cheng X. Mutation characteristics and molecular evolution of ovarian metastasis from gastric cancer and potential biomarkers for paclitaxel treatment. Nat Commun. 2024 May 4;15(1):3771. doi: 10.1038/s41467-024-48144-0. PMID: 38704377; PMCID: PMC11069556.

8. Yuan L, Pan L, Wang Y, Zhao J, Fang L, Zhou Y, Xia R, Ma Y, Jiang Z, Xu Z, Hu C, Wang Y, Zhang S, Zhang B, Ding H, Chen M, Cheng H, Goel A, Zhang Z, Cheng X. Characterization of the landscape of the intratumoral microbiota reveals that Streptococcus anginosus increases the risk of gastric cancer initiation and progression. Cell Discov. 2024 Nov 26;10(1):117. doi: 10.1038/s41421-024-00746-0. PMID: 39587089; PMCID: PMC11589709.

三、在研项目

团队带头人简介：汪强虎，博士，教授，博士生导师（外校兼职博导），江苏省杰出青年基金获得者，江苏省“333高层次人才工程”第二层次人才；曾在美国安德森癌症中心从事博士后研究工作，获Caroline Ross冠名杰出研究奖；南京医科大学生物信息学系主任、学科带头人，国家一流本科专业南医大生物信息学专业创建人、专业负责人。

中国神经学会神经肿瘤分会副主委，北京医学奖励基金会脑转移瘤专委会副主委，中国抗癌协会肿瘤标记物专委会青年副主委，中国抗癌协会肿瘤分子医学专委会常务委员，中国医师协会脑胶质瘤专委员会委员，中国医师协会脑胶质瘤专委会基础研究与转化专委会委员。

主要研究方向为肿瘤基因组学研究。在肿瘤分子异质性、微环境解构、肿瘤无创早期检测的分子标记识别、治疗抗性标记识别等方向具有研究优势；尤其在神经肿瘤研究中，从基因组学角度开展了系列突破性研究，研究方法和结论得到国内外同行的高度关注；近年来以通讯或一作在Cell、Cancer Discovery、Cancer Cell、Cancer Research、Blood、Neuro-Oncology、Nature Communications等杂志发表SCI论文近80篇；累计引用超10000次；单篇引用超1700次。

主持包括国家科技重大研发计划课题、国家自然科学基金重大研究计划、面上项目、江苏省杰出青年基金、江苏省重点研发计划等课题。

电子邮箱：wangqh@njmu.edu.cn

代表性论文：

1. Lingxiang Wu#, Wei Wu#, Junxia Zhang#, Zheng Zhao#, Liangyu Li, Mengyan Zhu, Min Wu, Fan Wu, Fengqi Zhou, Yuxin Du, Rui-Chao Chai, Wei Zhang, Xiaoguang Qiu, Quanzhong Liu, Ziyu Wang, Jie Li, Kening Li, Apeng Chen, Yinan Jiang, Xiangwei Xiao, Han Zou, Rashmi Srivastava, Tingting Zhang, Yun Cai, Yuan Liang, Bin Huang, Ruohan Zhang, Fan Lin, Lang Hu, Xiuxing Wang, Xu Qian, Sali Lv, Baoli Hu, Siyuan Zheng, Zhibin Hu, Hongbing Shen, Yongping You*, Roel G.W. Verhaak*, Tao Jiang*, and Qianghu Wang*.  Natural coevolution of tumor and immunoenvironment in glioblastoma. Cancer Discovery. 2022, https://doi.org/10.1158/2159-8290.CD-22-0196)

2. Wu M, Wu L, Wu W, Zhu M, Li J, Wang Z, Li J, Ding R, Liang Y, Li L, Zhang T, Huang B, Cai Y, Li K, Li L, Zhang R, Hu B, Lin F, Wang X, Zheng S, Chen J, You Y, Jiang T, Zhang J, Chen H, Wang Q*. Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages. Cancer Res. 2023 Mar 2;83(5):771-785.

3. Min Wu; Tingting Wang; Nan Ji; Ting Lu; Ran Yuan; Lingxiang Wu; Junxia Zhang; Mengyuan Li; Penghui Cao; Jiarui Zhao; Guanzhang Li; Jianyu Li; Yu Li; Yujie Tang; Zhengliang Gao; Xiuxing Wang; Wen Cheng; Ming Ge; Gang Cui; Qianghu Wang*; Jian Chen; Multi-omics and pharmacological characterization of patient-derived glioma cell lines, Nature Communications, 2024, 15(1):6740

4. Handong Sun; Lishen Zhang; Zhonglin Wang; Danling Gu; Mengyan Zhu; Yun Cai; Lu Li; Jiaqi Tang; Bin Huang; Bakwatanisa Bosco; Ning Li; Lingxiang Wu; Wei Wu; Liangyu Li; Yuan Liang; Lin Luo; Quanzhong Liu; Yanhui Zhu; Jie Sun; Liang Shi; Tiansong Xia; Chuang Yang; Qitong Xu; Xue Han; Weiming Zhang; Jianxia Liu; Dong Meng; Hua Shao; Xiangxin Zheng; Shuqin Li; Hua Pan; Jing Ke; Wenying Jiang; Xiaolan Zhang; Xuedong Han; Jian Chu; Hongyin An; Juyan Ge; Chi Pan; Xiuxing Wang; Kening Li; Qianghu Wang*; Qiang Ding ; Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer, Nature Communications, 2023, 14(1): 5590

5. Xiao Fan; Jintan Li; Bin Huang; Hongyu Lu; Chenfei Lu; Minhong Pan; Xiefeng Wang; Hongjian Zhang; Yongping You; Xiuxing Wang; Qianghu Wang*; Junxia Zhang ; Noninvasive radiomics model reveals macrophage infiltration in glioma, Cancer Letters, 2023, 573: 216380

6. Xia X, Li K, Wu L, Wang Z, Zhu M, Huang B, Li J, Wang Z, Wu W, Wu M, Li W, Li L, Cai Y, Bosco B, Zhong A, Liu X, Lv T, Gan Z, Chen G, Pan Y, Liu C, Zhang K, Xu X, Wang C, Wang Q*.  Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion. Blood. 2020 Aug 6;136(6):755-759.

7. Li K, Du Y, Cai Y, Liu W, Lv Y, Huang B, Zhang L, Wang Z, Liu P, Sun Q, Li N, Zhu M, Bosco B, Li L, Wu W, Wu L, Li J, Wang Q*, Hong M, Qian S. Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia. Leukemia. 2023 Feb;37(2):308-325.

8. Wang Q+, Hu B+, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW.  Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 Jul 10.

9. Hu B+, Wang Q+, Wang YA, Hua S, Sauve, GC, Ong DS, Zheng, DL, Chang Q, Ho YW, Monasterio, MM, Lu,X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao, W, Corley LJ, Yan H, Zhang J, You, Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RGW, DePinho RA.Epigenetic activation of WNT5A drives glioblastoma stem cell differentiation and invasive growth. Cell. 2016 Nov 17;167(5):1281-1295.e18.

在研项目：

团队带头人简介：章轶立，男，副教授，医学博士，硕士研究生导师，中西医结合学院循证与转化医学教研室副主任。硕博先后毕业于中国中医科学院、北京中医药大学。入选江苏省高层次人才培养计划（第七期“333工程”）、中华中医药学会青年人才托举工程、南京中医药大学C类特聘教授。主要从事老年病中西医结合防治规律与机理研究，中医药循证评价方法研究。主持国家自然科学基金项目、江苏省自然科学基金等项目8项，以第一作者/通讯作者发表学术论文60余篇，参编学术专著4部,“十四五”行业规划教材2部。获中国民族医药学会一等奖等奖励2项。兼任中华中医药学会骨伤科分会青年委员，世界中联骨质疏松专委会常务理事，世界中联中药上市后研究与评价专委会常务理事，《Acupuncture and Herbal Medicine》、《Science of Traditional Chinese Medicine》《中国实验方剂学杂志》青年编委，国家自然科学基金函评人。

电子邮箱：zhangyili823@126.com

一、团队研究方向

中医药防治骨质疏松症的基础与临床研究；

中医药循证评价方法研究；

中西医结合防治老年人共病创新研究。

二、研究内容

团队长期与国内外顶尖学者团队深度合作，致力于搭建开放、融通、互补的研究平台。近年来，聚焦中医药防治老年病（骨质疏松症）领域，在临床研究方面，构建了基于社区人群的骨质疏松症专病队列与生物样本库，开展了横断面与远期随访相结合的流行病学调查研究；基础研究方面，持续开展骨质疏松症早期风险预警机制研究、补肾方药治疗骨质疏松症疗效机理与转化应用研究。

三、发表论文（* 通讯/共同通讯作者；# 第一作者）

1. Xu Wei, Hao Xie, Can Liu, Yan Li, Kai Sun, Baoyu Qi, Xiangyun Guo, Zhaofeng Liu, Xinlin Huang, Chuanrui Sun, Jian Wang, Yili Zhang*, Lei Fan, Liguo Zhu. Nature Herbal Medicine- Tissue Engineering Strategies for Regulate Cell Homeostasis in Bone Regeneration. Adv. Funct. Mater. 2025, 2417810.  IF: 18.5

2. Wang L, Huang XY, Qin JR, Qi BY, Sun CR, Guo XY, Liu QQ, Liu YC, Ma Y, Wei X, Zhang YL*. The Role of Traditional Chinese Medicines in the Treatment of Osteoporosis. Am J Chin Med. 2024;52(4):949-986.  IF:4.8

3. Wang L, Guo XR, Qin JR, Jin ZK, Liu QQ, Sun CR, Sun K, Li LH, Wei X, Zhang YL*. Assessing the causal relationship between plasma proteins and osteoporosis: novel insights into pathological mechanisms and therapeutic implications. Osteoporos Int. 2024; 35(11): 1973-1987.  IF:4.2

4. Guo XY, She Y, Liu QQ, Qin JR, Wang L, Xu AL, Qi BY, Sun CR, Xie YM, Ma Y, Zhu LG, Tao WW, Wei X, Zhang YL*. Osteoporosis and depression in perimenopausal women: From clinical association to genetic causality. J Affect Disord. 2024; 356: 371-378.  IF:6.6

5. Liu C, Liu WL, Qi BY, Fan L, Liu SC, Yang QF, Yang YS, Yang SF, Zhang YL*, Wei X, Zhu L. Bone Homeostasis Modulating Orthopedic Adhesive for the Closed-Loop Management of Osteoporotic Fractures. Small. 2023; 19(48): e2302704.  IF:13.1

6. Zhang YL#, Huang XY, Qi BY, Sun CR, Sun K, Liu N, Zhu LG, Wei X. Ferroptosis and musculoskeletal diseases: "Iron Maiden" cell death may be a promising therapeutic target. Front Immunol. 2022; 13: 972753.  IF:8.7

7. Zhang YL#, Huang XY, Sun K, Li MY, Wang X, Han T, Shen H, Qi BY, Xie YM, Wei X. The Potential Role of Serum IGF-1 and Leptin as Biomarkers: Towards Screening for and Diagnosing Postmenopausal Osteoporosis. J Inflamm Res. 2022; 15: 533-543.  IF:6.9

8. 章轶立#,孙传睿,孙凯,等.从“骨健康计划”视角观照中医药防治骨质疏松症的时代价值与新思路[J].中国中药杂志,2025, 50(03): 569-574.

9. 章轶立#,齐保玉,孙传睿,等.重视机体铁代谢对骨质疏松症的影响及中医药调控效用[J].中国中药杂志,2025, 50(03): 575-582.

10. 章轶立#,黄馨懿,齐保玉,等. 老年人共病研究的现实意义、内容方法与前景展望 [J]. 中国循证医学杂志, 2023, 23(07): 862-868.

四、在研项目

团队带头人简介：成小兰，博士，副教授，硕士生导师，江苏省“333高层次人才培养工程”中青年科学技术带头人，江苏省“六大人才高峰”高层次人才选拔培养资助对象。以第一作者或通讯作者发表SCI论文十余篇；获中国发明专利14项，其中8项已授权。作为项目负责人，主持国家自然科学基金、国家重大新药创制项目子课题、江苏省重点研发计划（社会发展）等项目4项。获2023年江苏中医药科学技术奖三等奖1项。兼任中国中西医结合学会第九届基础理论专业委员会委员。

电子邮箱：chengxiaolan37@njucm.edu.cn

一、团队研究方向

课题组立足于中西医结合基础研究，聚焦中医药干预肿瘤相关脑病及血管性认知障碍的神经保护机制与转化应用研究，融合中医核心病机理论与现代分子生物学技术，解析中药活性成分及经典复方改善认知功能障碍的科学原理。

二、研究内容

研究内容主要包括：（1）中医药调控肿瘤相关脑病的分子机制；（2）血管性认知障碍（VCI）的中西医结合干预策略；（3）中药创新药物转化研究.课题组已成功制备项目研究中涉及的疾病模型，并建立了相应的行为学研究、原代细胞培养及其他分子生物学技术与方法。实验室设备齐全，管理完善，为项目的顺利实施提供坚实的技术保障。

三、发表论文

1. Lu LD, Shuang R, Cao F, Sun Z, Wei Q, Gao T, Gu X, Wen K, Cheng XL*, Gu MJ*. Emodin Inhibits AIM2 Inflammasome Activation via Modulating K27-Linked Polyubiquitination to Attenuate Renal Fibrosis. Phytother Res. 2024. doi: 10.1002/ptr.8390.

2. Wang Z^#, Cheng XL^#, Shuang R, Gao T, Zhao T, Hou D, Zhang Y, Yang J, Tao W. Dandouchi Polypeptide Alleviates Depressive-like Behavior and Promotes Hippocampal Neurogenesis by Activating the TRIM67/NF-κB Pathway in CUMS-Induced Mice. J Agric Food Chem. 2024, 72(30):16726-16738.

3. Yuan NN, Xu Y, Li X, Su Y, Wang ZD, Jiang RY, Shi HW, Tao WW, Zhang YF*, Ma JJ*, Cheng XL*. Danggui-Shaoyao San alleviates cognitive impairment via enhancing HIF-1α/EPO axis in vascular dementia rats. J Ethnopharmacol. 2024, 331:118306.

4. Cheng XL^#, Ruan YL^#, Dai JY^#, Fan HZ, Ling JY, Chen J, Lu WG, Gao XJ*, Cao P*. 8-Shogaol derived from dietary ginger alleviated acute and inflammatory pain by targeting TRPV1. Phytomedicine, 2024, 128: 155500.

5. Guo MM#, Wang ZD^#, Dai JY, Fan HZ, Yuan NN, Gao LM, Peng HP*, Cheng XL*. Glycyrrhizic acid alleviates liver fibrosis in vitro and in vivo via activating CUGBP1-mediated IFN-γ/STAT1/Smad7 pathway. Phytomedicine, 2023, 112: 154587.

6. Wang CG^#, Cheng XL^#, Peng H, Zhang YW*. NIR-Triggered and ROS-Boosted Nanoplatform for Enhanced Chemo/PDT/PTT Synergistic Therapy of Sorafenib in Hepatocellular Carcinoma. Nanoscale Res Lett. 2022, 17(1): 92.

7. Gu MJ, Zhou YF, Liao NK, Wei QX, Bai ZJ, Bao N, Zhu Y, Zhang H, Gao LP*, Cheng XL*. Chrysophanol, a main anthraquinone from Rheum palmatum L. (rhubarb), protects against renal fibrosis by suppressing NKD2/NF-κB pathway. Phytomedicine. 2022, 105: 154381.

8. Tao WW^#, Cheng XL^#, Sun DD, Guo Y, Wang N, Ruan J, Hu Y, Zhao M, Zhao T, Feng H, Fan L, Lu C, Ma Y*, Duan JA*, Zhao M*. Synthesis of multi-branched Au nanocomposites with distinct plasmon resonance in NIR-II window and controlled CRISPR-Cas9 delivery for synergistic gene-photothermal therapy. Biomaterials. 2022, 287: 121621.

9. Ruan YL^#, Ling JY^#, Ye F, Cheng N, Wu F, Tang ZX, Cheng XL*, Liu HQ*. Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway. Int Immunopharmacol. 2021, 101(Pt B):108364.

10. Lv ZM^#, Shen JY^#, Gao XJ, Ruan YL, Ling JY, Sun RW, Dai JY, Fan HZ, Cheng XL*; Cao P*. Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress, Chinese Medicine, 2021, 16(1): 76.

四、在研项目

团队带头人简介：胡玥，博士，副教授，硕士生导师。江苏省“双创博士”（世界名校类），江苏省“333工程”第三层次培养对象，江苏省中医药管理局青年科技人才。博士毕业于德国慕尼黑大学，主要从事中西医结合防治脑病及大数据相关研究。主持国家自然科学基金、江苏省自然科学基金等各级各类项目7项，以第一/通讯作者在国内外学术刊物Journal of Advanced Research, Journal of Nanobiotechnology, Phytomedicine等杂志发表SCI论文17篇；兼任中国中医药信息学会全科医学分会常务理事兼副秘书长、中华中医药学会脑病分会青年委员、中国研究型医院学会神经再生与修复专业委员会委员、南京中医药学会脑病分会委员。兼任《Science of Traditional Chinese Medicine》、《Neural Regeneration Research》等杂志青年编委；Advanced Science、Journal of Ethnopharmacology, The American Journal of Chinese Medicine, Journal of Food Biochemistry等期刊审稿人。

电子邮箱：yuehu@njucm.edu.cn

一、研究方向

围绕抑郁症、缺血性中风等疾病进行中医理论指导下的经典名方治疗脑病研究，立足中西医结合学科属性，针对抑郁症深入探究与挖掘中药复方基于“胶质细胞-神经元”单元，解决一线抗抑郁药物起效慢、存在不良反应、敏感性低的问题，为临床抗抑郁治疗提供借鉴；针对血脑屏障研究探索血脑屏障在病理状态下的微环境及通透性变化，深入研究药物透血脑屏障到达机体作用靶点的可行性，特别关注“活血化瘀”的时序性差异，为临床治疗缺血性中风提供了新的药物治疗靶点及机制。

二、研究内容

深入探究中药复方在抗抑郁以及防止脑缺血再灌注损伤等方面的具体机制，明确了其有效成分在抗抑郁作用、神经保护和认知改善等多个领域方面的分子机制，以及脑缺血再灌注损伤中涉及的铁死亡、神经炎症、线粒体功能等多个生物学过程；同时研究脑损伤后血脑屏障破损引起的微环境及血脑屏障通透性的变化，针对小胶质细胞与神经元的相互作用进行了探索，为理解神经系统疾病的病理生理学机制和治疗提供了新的视角。

三、发表论文

1. Hu Y, Tao W. Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction. J Adv Res. 2024;66:251-265. doi:10.1016/j.jare.2024.01.006 . IF: 11.4

2. Tao W, Ruan J, Hu Y*, et al. A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling. J Adv Res. 2023;43:219-231. doi:10.1016/j.jare.2022.02.015. IF: 11.4

3. Hu Y#, Zhao M#, Wang H#, et al. Exosome-sheathed ROS-responsive nanogel to improve targeted therapy in perimenopausal depression. J Nanobiotechnology. 2023;21(1):261. Published 2023 Aug 8. doi:10.1186/s12951-023-02005-y. IF: 10.6

4. Yang Z, Zhao Y, Wang Y, Hu Y* et al. Echinacoside ameliorates post-stroke depression by activating BDNF signaling through modulation of Nrf2 acetylation. Phytomedicine. 2024;128:155433. doi:10.1016/j.phymed.2024.155433. IF: 6.7

5. Ye Z, Wang J, Fang F, Hu Y* et al. Zhi-Zi-Hou-Po decoction alleviates depressive-like behavior and promotes hippocampal neurogenesis in chronic unpredictable mild stress induced mice via activating the BDNF/TrkB/CREB pathway. J Ethnopharmacol. 2024;319(Pt 3):117355. doi:10.1016/j.jep.2023.117355. IF: 4.8

6. Qian L, Huang S, Liu X, Hu Y* et al. Morroniside improves the symptoms of post-stroke depression in mice through the BDNF signaling pathway mediated by MiR-409-3p.Phytomedicine. 2024;123:155224. doi:10.1016/j.phymed.2023.155224.  IF:6.7

7. Hu Y, Zhao M, Zhao T, et al. The Protective Effect of Pilose Antler Peptide on CUMS-Induced Depression Through AMPK/Sirt1/NF-κB/NLRP3-Mediated Pyroptosis. Front Pharmacol. 2022;13:815413. Published 2022 Mar 23. doi:10.3389/fphar.2022.815413. IF:6.0

8. Feng H, Xue M, Hu Y*et al. Ginsenoside and Its Therapeutic Potential for Cognitive Impairment. Biomolecules. 2022;12(9):1310. Published 2022 Sep 16. doi:10.3390/biom12091310. IF:6.0

9. Hu Y, Burcu Seker, Carina Exner,et al. Longitudinal Characterization of Blood-Brain Barrier Permeability after Experimental Traumatic Brain Injury by In Vivo 2-Photon Microscopy. J Ethnopharmacol,2021 Feb 15;38(4):399-410. doi: 10.1089/neu.2020.7271. IF:5.1

10. Yang Y, Wu Q, Hu Y*, et al. Ginkgolide B attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through disrupting NCOA4-FTH1 interaction. J Ethnopharmacol, 2024 Jan 10;318(Pt B):116982. IF: 4.8

四、在研项目